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The Role of Autophagy in the Maintenance of Mitochondrial Quality and Adaptations to Contractile Activity
Autophagy is a critical survival mechanism facilitating protein turnover and pathogen defense in post-mitotic cells. More recently, mitophagy has been identified for the selective recognition and targeting of mitochondria ...
AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
There are multiple copies of mtDNA per cell and each mtDNA molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated ...