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AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
There are multiple copies of mtDNA per cell and each mtDNA molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated ...
The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. ...
The Role of Autophagy in the Maintenance of Mitochondrial Quality and Adaptations to Contractile Activity
Autophagy is a critical survival mechanism facilitating protein turnover and pathogen defense in post-mitotic cells. More recently, mitophagy has been identified for the selective recognition and targeting of mitochondria ...
The Role of PGC-1 alpha in Mediating Exercise-Induced TFEB Expression and Activity in Skeletal Muscle
A healthy mitochondrial pool in skeletal muscle is maintained by the coordinated processes of biogenesis and mitophagy. PGC-1alpha is a key transcriptional co-activator necessary for mitochondrial synthesis, whereas ...
Effect of Tim23 Knockdown IN VIVO on Protein Import into Mitochondria and Retrograde Signaling to the UPRmt in Muscle
The mitochondrial unfolded protein response (UPRmt) is a protein quality control mechanism that strives to eliminate toxic effects exerted by misfolded and misassembled proteins. We sought to understand this mechanism by ...
Exploration of the Mitochondria as a Potential Therapeutic Target in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease resulting from a mutation in the X-linked gene encoding the protein dystrophin. DMD is characterized by profound muscle weakness as degenerating ...