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The Role of Autophagy in the Maintenance of Mitochondrial Quality and Adaptations to Contractile Activity
Autophagy is a critical survival mechanism facilitating protein turnover and pathogen defense in post-mitotic cells. More recently, mitophagy has been identified for the selective recognition and targeting of mitochondria ...
The Role of PGC-1 alpha in Mediating Exercise-Induced TFEB Expression and Activity in Skeletal Muscle
A healthy mitochondrial pool in skeletal muscle is maintained by the coordinated processes of biogenesis and mitophagy. PGC-1alpha is a key transcriptional co-activator necessary for mitochondrial synthesis, whereas ...