Now showing items 1-7 of 7
A Mechanism for Blood Flow-Induced Capillary Maintenance
High blood flow is important for the proper functioning of blood vessels. One of the ways this occurs is by production of protease inhibitors, which maintain vessel wall integrity.
Sex-Related Differences in Microvascular Adaptations to Obesity
Capillaries within skeletal muscle and adipose tissue have a critical role in the maintenance of proper tissue function. A reduction in capillary density is correlated with impairments in metabolism. The susceptibility to ...
Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications
Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells ...
Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue Than Males in Response to High-Fat Diet
Background: Impaired capillary growth (angiogenesis) in skeletal muscle and adipose tissue contributes to the development of metabolic disorders in obese males. This association remains unexplored in females, despite ...
Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
Considerable effort has been directed towards the development of preventative and therapeutic strategies against obesity and its clinical sequalae that now pose a significant public health and economic burden on healthcare ...
Sex Differences in Endothelial Cell Angiogenic Capacity
There is a sex-specific difference in susceptibility to develop obesity-related disorders. Our labs previous study on high-fat fed mice indicated higher angiogenesis in visceral adipose tissue of female mice, which accompanied ...
The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia
Muscle regeneration requires inflammation followed by microvascular growth and blood-flow recovery; however, these are impaired in ischemic muscle of peripheral artery disease patients. Endothelial cell (EC)-specific ...