Bergmans, LonnekeSnijdelaar, Dirk GKatz, JoelCrul, Ben J. P2013-10-202013-10-202002-05Clin J Pain. 2002 May-Jun;18(3):203-5.SSN: 0749-8047, ESSN: 1536-5409http://hdl.handle.net/10315/26494Objective: The objective of this case series was to determine if severe phantom limb pain could be reduced with oral methadone. Design: Four cases of phantom limb pain refractory to multiple treatment modalities were treated with oral methadone. Setting: Pain clinic at a major university medical center. Patients: Four patients with severe, intractable phantom limb pain. Intervention: Oral methadone was administered, starting with a low dose of 2 to 5 mg twice a day or three times a day and slowly titrated upward to achieve pain relief. Outcome Measures: Repeated administration of a visual analog scale for pain. Results and Conclusions: Administration of oral methadone may be of value in the treatment of phantom limb pain; controlled clinical trials would be appropriate to verify this observation.en-USMethadone, Phantom limb painArticlehttp://journals.lww.com/clinicalpain/pages/default.aspxhttp://www.lww.comhttp://journals.lww.com/clinicalpain/Abstract/2002/05000/Methadone_for_Phantom_Limb_Pain.12.aspx