Goldberg, Robert J.Katz, Joel2011-05-192011-05-192007Pain, 129(1-2), 210-223. (2007)http://hdl.handle.net/10315/7974Between 40% and 60% of Americans use complementary and alternative medicine to manage medical conditions, prevent disease, and promote health and well-being. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been used to treat joint pain associated with several inflammatory conditions. We conducted a meta-analysis of 17 randomized, controlled trials assessing the pain relieving effects of ω-3 PUFAs in patients with rheumatoid arthritis or joint pain secondary to inflammatory bowel disease and dysmenorrhea. Meta-analysis was conducted with Cochrane Review Manager 4.2.8. for six separate outcomes using standardized mean differences (SMDs) as a measure of effect size: (1) patient assessed pain, (2) physician assessed pain, (3) duration of morning stiffness, (4) number of painful and/or tender joints, (5) Ritchie articular index, and (6) nonselective nonsteroidal anti-inflammatory drug consumption. Supplementation with ω-3 PUFAs for 3–4 months reduces patient reported joint pain intensity (SMD: −0.26; 95% CI: −0.49 to −0.03, p = 0.03), minutes of morning stiffness (SMD: −0.43; 95% CI: −0.72 to −0.15, p = 0.003), number of painful and/or tender joints (SMD: −0.29; 95% CI: −0.48 to −0.10, p = 0.003), and NSAID consumption (SMD: −0.40; 95% CI: −0.72 to − 0.08, p = 0.01). Significant effects were not detected for physician assessed pain (SMD: −0.14; 95% CI: −0.49 to 0.22, p = 0.45) or Ritchie articular index (SMD: 0.15; 95% CI: − 0.19 to 0.49, p = 0.40) at 3–4 months. The results suggest that ω-3 PUFAs are an attractive adjunctive treatment for joint pain associated with rheumatoid arthritis, inflammatory bowel disease, and dysmenorrhea.enmeta-analysisinflammatory bowel diseasedysmenorrheaRCTrheumatoid arthritisjoint paininflammationfish oilDHAEPAomega-3 polyunsaturated fatty acidsArticlehttp://www.elsevier.com/wps/find/journaldescription.cws_home/506083/description#descriptionhttp://www.elsevier.comhttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0K-4N5CSS8-4-1&_cdi=4865&_user=866177&_pii=S0304395907000413&_origin=gateway&_coverDate=05%2F31%2F2007&_sk=998709998&view=c&wchp=dGLzVzb-zSkzS&md5=2d934a9e0cfa112d4e7e9c9708b072b7&ie=/sdarticle.pdf