Katie Dogantzis Microsoft Office User 2016-10-27T12:53:05Z 2016-12-22T18:29:09Z 15.0 96 18680 28540 3760 700 600 1 False False Table 1.1 DAVID GO Enichment Clusters for genes with gamma > 1, with a combined enrichment score Pvalue < 0.05 Annotation Cluster 1 Enrichment Score: 2.71 Searchable Terms Count P_Value Benjamini INTERPRO Zinc finger, FYVE/PHD-type IPR011011 17 1.1E-4 0.11 INTERPRO Zinc finger, RING/FYVE/PHD-type IPR013083 29 7.1000000000000002E-4 0.32 INTERPRO Zinc finger, PHD-type IPR001965 11 9.2000000000000003E-4 0.28999999999999998 SMART PHD SM00249 11 1.1000000000000001E-3 0.22 INTERPRO Zinc finger, PHD-finger IPR019787 9 8.6999999999999994E-3 0.8 INTERPRO Zinc finger, PHD-type, conserved site IPR019786 7 8.8999999999999996E-2 0.98 Annotation Cluster 2 Enrichment Score: 2.3 Searchable Terms Count P_Value Benjamini GOTERM_BP_ALL cellular lipid metabolic process GO:0044255 37 9.1E-4 0.64 GOTERM_BP_ALL lipid metabolic process GO:0006629 41 1.0999999999999999E-2 0.86 GOTERM_BP_ALL lipid biosynthetic process GO:0008610 22 1.2E-2 0.86 Annotation Cluster 3 Enrichment Score: 2.25 Searchable Terms Count P_Value Benjamini GOTERM_MF_ALL DNA-directed RNA polymerase activity GO:0003899 11 2.5999999999999998E-4 0.22 GOTERM_MF_ALL RNA polymerase activity GO:0034062 11 2.5999999999999998E-4 0.22 KEGG_PATHWAY RNA polymerase dme03020 10 4.0999999999999999E-4 4.1000000000000002E-2 GOTERM_CC_ALL transferase complex, transferring phosphorus-containing groups GO:0061695 28 4.6000000000000001E-4 0.12 GOTERM_MF_DIRECT DNA-directed RNA polymerase activity GO:0003899 10 5.1000000000000004E-4 0.26 GOTERM_CC_ALL nuclear DNA-directed RNA polymerase complex GO:0055029 21 7.9000000000000001E-4 0.14000000000000001 GOTERM_CC_ALL DNA-directed RNA polymerase complex GO:0000428 21 9.1E-4 0.12 GOTERM_CC_ALL RNA polymerase complex GO:0030880 21 9.1E-4 0.12 GOTERM_BP_ALL transcription from RNA polymerase I promoter GO:0006360 8 1.2999999999999999E-3 0.66 GOTERM_BP_DIRECT transcription from RNA polymerase III promoter GO:0006383 7 1.8E-3 0.56000000000000005 KEGG_PATHWAY Pyrimidine metabolism dme00240 14 8.8999999999999999E-3 0.2 GOTERM_BP_ALL transcription from RNA polymerase III promoter GO:0006383 7 9.1999999999999998E-3 0.87 GOTERM_CC_DIRECT DNA-directed RNA polymerase III complex GO:0005666 6 1.2999999999999999E-2 0.78 GOTERM_CC_ALL DNA-directed RNA polymerase III complex GO:0005666 6 1.2999999999999999E-2 0.56999999999999995 KEGG_PATHWAY Purine metabolism dme00230 17 1.4999999999999999E-2 0.27 GOTERM_CC_ALL catalytic complex GO:1902494 63 2.5000000000000001E-2 0.66 GOTERM_CC_DIRECT DNA-directed RNA polymerase I complex GO:0005736 5 2.8000000000000001E-2 0.85 GOTERM_CC_ALL DNA-directed RNA polymerase I complex GO:0005736 5 2.8000000000000001E-2 0.65 GOTERM_BP_DIRECT transcription from RNA polymerase I promoter GO:0006360 5 0.03 0.99 UP_KEYWORDS Nucleotidyltransferase Nucleotidyltransferase 13 3.5999999999999997E-2 0.44 GOTERM_MF_ALL nucleotidyltransferase activity GO:0016779 14 5.1999999999999998E-2 0.84 GOTERM_CC_ALL transferase complex GO:1990234 41 7.1999999999999995E-2 0.81 UP_KEYWORDS DNA-directed RNA polymerase DNA-directed RNA polymerase 5 8.3000000000000004E-2 0.6 GOTERM_CC_ALL nucleoplasm part GO:0044451 35 8.3000000000000004E-2 0.83 Annotation Cluster 4 Enrichment Score: 2.22 Searchable Terms Count P_Value Benjamini GOTERM_BP_ALL RNA 3'-end processing GO:0031123 18 8.4999999999999999E-6 2.8000000000000001E-2 GOTERM_BP_ALL mRNA 3'-end processing GO:0031124 9 3.0000000000000001E-3 0.81 GOTERM_BP_ALL mRNA polyadenylation GO:0006378 8 5.8999999999999999E-3 0.81 GOTERM_BP_ALL RNA polyadenylation GO:0043631 8 9.4999999999999998E-3 0.84 GOTERM_BP_DIRECT mRNA polyadenylation GO:0006378 6 3.6999999999999998E-2 0.99 GOTERM_BP_ALL mRNA processing GO:0006397 21 0.92 1 Annotation Cluster 5 Enrichment Score: 2.14 Searchable Terms Count P_Value Benjamini INTERPRO Zinc finger, C2H2-like IPR015880 20 4.0000000000000001E-3 0.67 SMART ZnF_C2H2 SM00355 20 4.8999999999999998E-3 0.44 INTERPRO Zinc finger, C2H2 IPR007087 21 8.3999999999999995E-3 0.84 GOTERM_MF_DIRECT nucleic acid binding GO:0003676 35 9.9000000000000008E-3 0.95 INTERPRO Zinc finger C2H2-type/integrase DNA-binding domain IPR013087 16 1.2E-2 0.86 Annotation Cluster 6 Enrichment Score: 1.93 Searchable Terms Count P_Value Benjamini GOTERM_BP_ALL monocarboxylic acid biosynthetic process GO:0072330 8 1.2999999999999999E-3 0.66 GOTERM_BP_ALL fatty acid biosynthetic process GO:0006633 8 1.2999999999999999E-3 0.66 GOTERM_BP_ALL organic acid biosynthetic process GO:0016053 14 2.8E-3 0.85 GOTERM_BP_ALL monocarboxylic acid metabolic process GO:0032787 19 3.5999999999999999E-3 0.78 GOTERM_BP_ALL fatty acid metabolic process GO:0006631 14 3.8999999999999998E-3 0.76 GOTERM_BP_ALL small molecule biosynthetic process GO:0044283 19 6.3E-3 0.8 GOTERM_BP_ALL carboxylic acid biosynthetic process GO:0046394 12 7.9000000000000008E-3 0.85 UP_KEYWORDS Fatty acid metabolism Fatty acid metabolism 6 0.01 0.47 GOTERM_BP_DIRECT fatty acid biosynthetic process GO:0006633 5 2.1999999999999999E-2 0.99 GOTERM_BP_ALL carboxylic acid metabolic process GO:0019752 31 2.9000000000000001E-2 0.94 GOTERM_BP_ALL oxoacid metabolic process GO:0043436 31 0.03 0.94 UP_KEYWORDS Lipid metabolism Lipid metabolism 10 3.7999999999999999E-2 0.44 UP_KEYWORDS Fatty acid biosynthesis Fatty acid biosynthesis 4 4.5999999999999999E-2 0.47 GOTERM_BP_ALL organic acid metabolic process GO:0006082 32 0.1 0.97 UP_KEYWORDS Lipid biosynthesis Lipid biosynthesis 6 0.11 0.65 Annotation Cluster 7 Enrichment Score: 1.92 Searchable Terms Count P_Value Benjamini UP_KEYWORDS Secreted Secreted 17 4.7999999999999996E-3 0.46 GOTERM_CC_DIRECT extracellular region GO:0005576 25 1.4999999999999999E-2 0.71 GOTERM_CC_ALL extracellular region GO:0005576 42 2.4E-2 0.68 Annotation Cluster 8 Enrichment Score: 1.72 Searchable Terms Count P_Value Benjamini GOTERM_BP_ALL transcription from RNA polymerase I promoter GO:0006360 8 1.2999999999999999E-3 0.66 GOTERM_BP_ALL positive regulation of transcription from RNA polymerase I promoter GO:0045943 3 4.9000000000000002E-2 0.95 GOTERM_BP_ALL regulation of transcription from RNA polymerase I promoter GO:0006356 3 0.11 0.97 Annotation Cluster 9 Enrichment Score: 1.67 Searchable Terms Count P_Value Benjamini UP_KEYWORDS Zinc Zinc 57 2.0999999999999999E-3 0.42 UP_KEYWORDS Zinc-finger Zinc-finger 39 1.0999999999999999E-2 0.37 UP_KEYWORDS Metal-binding Metal-binding 79 1.2E-2 0.36 GOTERM_MF_ALL metal ion binding GO:0046872 119 2.9000000000000001E-2 0.89 GOTERM_MF_ALL cation binding GO:0043169 119 3.2000000000000001E-2 0.86 GOTERM_MF_ALL ion binding GO:0043167 123 3.4000000000000002E-2 0.86 GOTERM_MF_ALL transition metal ion binding GO:0046914 56 3.5000000000000003E-2 0.85 GOTERM_MF_ALL zinc ion binding GO:0008270 48 0.04 0.85 GOTERM_MF_DIRECT zinc ion binding GO:0008270 48 0.04 0.99 GOTERM_MF_DIRECT metal ion binding GO:0046872 54 4.2999999999999997E-2 0.97 Annotation Cluster 10 Enrichment Score: 1.44 Searchable Terms Count P_Value Benjamini INTERPRO CD36 antigen IPR002159 4 2.3E-2 0.96 GOTERM_MF_DIRECT scavenger receptor activity GO:0005044 5 0.04 0.98 GOTERM_MF_ALL scavenger receptor activity GO:0005044 5 0.04 0.84 GOTERM_MF_ALL cargo receptor activity GO:0038024 6 4.7E-2 0.86 Annotation Cluster 11 Enrichment Score: 1.43 Searchable Terms Count P_Value Benjamini GOTERM_BP_ALL ncRNA 3'-end processing GO:0043628 9 4.7999999999999996E-3 0.77 GOTERM_BP_ALL snRNA 3'-end processing GO:0034472 7 1.4999999999999999E-2 0.9 GOTERM_BP_ALL snRNA processing GO:0016180 7 2.3E-2 0.94 GOTERM_BP_ALL snRNA metabolic process GO:0016073 8 2.5000000000000001E-2 0.93 GOTERM_CC_ALL integrator complex GO:0032039 5 3.6999999999999998E-2 0.71 GOTERM_CC_DIRECT integrator complex GO:0032039 5 3.6999999999999998E-2 0.83 GOTERM_BP_DIRECT snRNA 3'-end processing GO:0034472 5 3.9E-2 0.99 GOTERM_CC_ALL DNA-directed RNA polymerase II, holoenzyme GO:0016591 11 0.2 0.91 GOTERM_BP_DIRECT snRNA processing GO:0016180 3 0.28999999999999998 1 Annotation Cluster 12 Enrichment Score: 1.42 Searchable Terms Count P_Value Benjamini GOTERM_BP_ALL DNA metabolic process GO:0006259 35 9.4999999999999998E-3 0.86 GOTERM_BP_ALL DNA repair GO:0006281 21 2.8000000000000001E-2 0.94 GOTERM_BP_ALL cellular response to DNA damage stimulus GO:0006974 34 3.7999999999999999E-2 0.95 GOTERM_BP_ALL cellular response to stress GO:0033554 57 0.2 0.99 Annotation Cluster 13 Enrichment Score: 1.36 Searchable Terms Count P_Value Benjamini UP_KEYWORDS Fatty acid metabolism Fatty acid metabolism 6 0.01 0.47 KEGG_PATHWAY Biosynthesis of unsaturated fatty acids dme01040 4 4.7E-2 0.46 GOTERM_BP_DIRECT lipid metabolic process GO:0006629 6 0.17 1 Annotation Cluster 14 Enrichment Score: 1.3 Searchable Terms Count P_Value Benjamini GOTERM_MF_DIRECT phosphopantetheine binding GO:0031177 3 2.7E-2 0.98 GOTERM_MF_ALL phosphopantetheine binding GO:0031177 3 2.7E-2 0.93 GOTERM_MF_ALL modified amino acid binding GO:0072341 4 4.9000000000000002E-2 0.86 INTERPRO Acyl carrier protein-like IPR009081 3 7.4999999999999997E-2 0.98 GOTERM_MF_ALL vitamin binding GO:0019842 5 0.12 0.96