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Epidural ketamine for postoperative analgesia

dc.contributor.authorSandler, Alan, N.
dc.contributor.authorSchmid, Roger
dc.contributor.authorKatz, Joel
dc.date.accessioned2013-10-20T15:05:24Z
dc.date.available2013-10-20T15:05:24Z
dc.date.issued1998-02
dc.description.abstractTwo factors have increased interest in ketamine for postoperative analgesia. The first was the discovery of the N-Methyl-D-asparrate (NMDA) receptor and its role in central pain processing and spinal cord neural plasticity.1 Ketamine is one of two clinically useful NMDA receptor antagonists available (the other is dextromethorphan). Ketamine binds non-competitively to the PCI, (phencyclidine) recognition site in the NMDA receptor channel2. In addition, interest in the concept of preemptive analgesia makes ketamine a natural candidate for investigation of ...en_US
dc.description.abstractDeux facteurs ont accru l'intérêt envers la kétamine pour l'analgésie postopératoire. Le premier a été la découverte du récepteur N-méthyl-D-aspartate (NMDA) et de son rô1e dans le traitement central de la douleur et dans la plasticité neurale de la moelle1. La kétamine est l'un des deux antagonistes du récepteur NMDA cliniquement intéressants, l'autre étant le dextrométhorphan. La kétamine se lie de façon non compétitive au site de reconnaissance PCI (phencyclidine) dans le canal du récepteur NMDA2. En outre, l'intérêt pour le concept d'analgésie préemptive fait de la kétamine un candidat naturel …en_US
dc.identifier.citationCanadian Journal of Anaesthesia, February 1998, Volume 45, Issue 2, pp 99-102
dc.identifier.issnISSN: 0832-610X (Print) 1496-8975 (Online)
dc.identifier.urihttp://hdl.handle.net/10315/26483
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.rightsThe final publication is available at http://link.springer.com/article/10.1007%2FBF03013245en_US
dc.rights.articlehttp://link.springer.com/article/10.1007%2FBF03013245
dc.rights.journalhttp://link.springer.com/journal/12630en_US
dc.rights.publisherhttp://link.springer.com/en_US
dc.subjectPost-operative pain, morphine, ketamine, NMDA receptor antagonist, epidural analgesiaen_US
dc.titleEpidural ketamine for postoperative analgesia
dc.title.alternativeKétamine péridurale pour l'analgésie postopératoireen_US
dc.typeArticleen_US

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