Proline/Alanine Tails as Ionization Enhancement Tags in Native Mass Spectrometry
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Date
2023-05-12
Authors
Abdalla, Marwa
Lento, Cristina
Jiang, Guifeng
Power, Austin
Wilson, Derek
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Abstract
This study aimed to study the impact of Proline/Alanine tag on l-asparaginase protein dynamics.
Our current analysis demonstrates that the PA tail fragment did not change the core protein dynamics using TRESI HDX MS to provide identical stability with untagged l-asparaginase.
Novel Aspects In this work, we propose PASylation ® as a new tool for ionization enhancement through chain ejection.
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Marwa ElSabaawy, Cristina Lento and Guifeng Jiang et al. Proline/Alanine Tails as Ionization Enhancement Tags in Native Mass Spectrometry. ScienceOpen Posters. 2023. DOI: 10.14293/P2199-8442.1.SOP-.PYK0FB.v1