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Physical health status assessed during hospitalization for acute coronary syndrome predicts mortality 12 months later

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dc.contributor.authorStewart, Donna Eileen
dc.contributor.authorZiegelstein, R.C.
dc.contributor.authorThombs, Brett
dc.contributor.authorParakh, K.
dc.contributor.authorAbbey, Susan E.
dc.contributor.authorGrace, Sherry L.
dc.date.accessioned2009-05-29T18:10:59Z
dc.date.available2009-05-29T18:10:59Z
dc.date.issued2008-12
dc.description.abstractObjective: Self-report measures of health status predict mortality in several groups of patients with cardiovascular disease, although overlap with symptoms of depression may reduce or eliminate this relationship. The association between self-reported health status and mortality has not been examined in patients hospitalized for acute coronary syndrome (ACS). The objective was to investigate whether the Physical Component Summary (PCS) and Mental Component Summary (MCS) scores of the SF12 predicted 12-month all-cause mortality after controlling for cardiac risk factors and symptoms of depression. Methods: The SF-12 and Beck Depression Inventory were administered 2-5 days after admission to 800 ACS patients from 12 coronary care units. Logistic regression was used to assess the relationship of the PCS and MCS with mortality 12 months later, controlling for age, sex, cardiac diagnosis (acute myocardial infarction vs. unstable angina), Killip class, history of myocardial infarction, and in-hospital depressive symptoms. Results: Lower scores on the SF-12 PCS (worse health) were associated with a significantly higher risk of mortality [odds ratio (OR)=0.94, 95% confidence interval (CI)=0.92-0.97, P<.OOI]. MCS scores failed to reach significance (OR=0.98, CI=0.95-1.00, P=.053). The PCS significantly predicted mortality even after controlling for other cardiac risk factors and depressive symptoms (OR=0.96, CI=0.93-0.99, P=.008), equivalent to a 34% increase in risk per lO-point (I SD) decrement in PCS scores. Conclusion: The brief SF-12 PCS presents an attractive option for improving risk stratification among hospitalized ACS patients.en
dc.description.sponsorshipThis research was conducted with funds from the Heart and Stroke Foundation of Ontario and the Samuel Lunenfeid Foundation of Toronto, Ontario, awarded to Dr. Stewart and Dr. Abbey. Dr. Thombs is supported by a New Investigator Award from the Canadian Institutes of Health Research and an Etablissement de Jeunes Chercheurs award from the Fonds de la Recherche en Sante Quebec. Dr. Grace receives funding from the Canadian Institutes of Health Research, and Dr. Ziegeistein is supported by grant number R24AT00464l from the National Center for Complementary & Alternative Medicine and by the Miller Family Scholar Program.
dc.description.sponsorshipThis research was conducted with funds from the Heart and Stroke Foundation of Ontario and the Samuel Lunenfeid Foundation of Toronto, Ontario, awarded to Dr. Stewart and Dr. Abbey. Dr. Thombs is supported by a New Investigator Award from the Canadian Institutes of Health Research and an Etablissement de Jeunes Chercheurs award from the Fonds de la Recherche en Sante Quebec. Dr. Grace receives funding from the Canadian Institutes of Health Research, and Dr. Ziegeistein is supported by grant number R24AT00464l from the National Center for Complementary & Alternative Medicine and by the Miller Family Scholar Program.en
dc.identifier.citationJournal of Psychosomatic Research, 65(6), 587-593
dc.identifier.issn0022-3999
dc.identifier.urihttp://hdl.handle.net/10315/2572
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpsychores.2008.06.004
dc.language.isoenen
dc.publisherElsevier
dc.subjectAcute coronary syndrome
dc.subjectMortality
dc.subjectQuality of life
dc.subjectSF-12
dc.titlePhysical health status assessed during hospitalization for acute coronary syndrome predicts mortality 12 months later
dc.typeArticle

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